안녕하세요?
어제는 안식일이라서 인터넷을 열어보지 못해 답변이 늦어져 죄송합니다.
물론 제가 실험을 해본 것은 사실입니다.
아무리 사실이라해도 믿지 못하겠다하면 할 말은 없지요.
그러나 이 과학적 사실은 저 뿐만 아니라 세계적으로 유명한 과학자들에 의하여 이미
밝혀진 것이기 때문에 논문을 하나 올려 드리려 합니다. 영문으로 되어 있는 점 양해해 주시고
필요하신 분들께 알려주시기 바랍니다.
Liver Regeneration
George K. Michalopoulos * and Marie C. DeFrances
Liver regeneration after the loss of hepatic tissue is a fundamental parameter of liver response to injury. Recognized as a phenomenon from mythological times, it is now defined as an orchestrated response induced by specific external stimuli and involving sequential changes in gene expression, growth factor production, and morphologic structure. Many growth factors and cytokines, most notably hepatocyte growth factor, epidermal growth factor, transforming growth factor-, interleukin-6, tumor necrosis factor-, insulin, and norepinephrine, appear to play important roles in this process. This review attempts to integrate the findings of the last three decades and looks toward clues as to the nature of the causes that trigger this fascinating organ and cellular response.
Liver regeneration, having presumably evolved to protect animals in the wild from the catastrophic results of liver loss caused by food toxins, has been an object of curiosity for many years. The ancient Greeks recognized liver regeneration in the myth of Prometheus. Having stolen the secret of fire from the gods of Olympus, Prometheus was condemned to having a portion of his liver eaten daily by an eagle. His liver regenerated overnight, thus providing the eagle with eternal food and Prometheus with eternal torture. In modern times, the best experimental model for the study of liver regeneration is that introduced by Higgins and Anderson (1): a simple operation (partial hepatectomy, PHx) in which two-thirds of the liver of a rat is removed. Specific liver lobes are removed intact, without damage to the lobes left behind. The residual lobes enlarge to make up for the mass of the removed lobes, though the resected lobes never grow back. The whole process lasts 5 to 7 days. Partial hepatectomy is the most often used stimulus to study liver regeneration because, compared with other methods that use hepatic toxins (such as CCl4), it is not associated with tissue injury and inflammation, and the initiation of the regenerative stimulus is precisely defined (removal of liver lobes).
Studies with hepatic resections in larger animals (dogs and primates) and humans have established that the regenerative response is proportional to the amount of liver removed. Even small resections (<10%) are followed by eventual restoration of the liver to full size. When liver from large dogs is transplanted into small dogs, liver size gradually decreases until the size of the organ becomes proportional to the new body size (2). Conversely, in two recent cases of baboon liver transplanted to humans, the transplanted intact liver of the baboon rapidly grew in size (within a week) until it reached the size of human liver (3). These studies demonstrate that liver mass is precisely regulated and that signals from the body can have negative as well as positive effects on liver mass until the correct size is reached
The authors are in the Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Full text를 보시기 원하시면 Science 1997. April 4;276: 60-66쪽을 참고하시면 간의 재생에 대하여
매우 자세하게 게재 되어 있습니다.
간을 부분이식하는 이유도 간이 재생하는 원리 때문입니다.
지금은 간 뿐만 아니라 뇌신경, 심장근육, 신장 등 모든 세포들이 재생한다는 것이 분명히 밝혀져
있습니다. 창조주께서 살아 계시기 때문에 가능한 일입니다.
감사합니다.
================================
┼ ▨ 유박사님, 이 문제 중요합니다!!! - 재림교인(aabb22@chollian.net) ┼
│ 왜 답변이 없으신가요?
│ 유박사님의 "최첨단의학 재생"편에 기록된
│ 대학 4년때의 개 간 절제 수술이 사실인가요?
│ 꼭 답변해 주십시요
│ 지금 몇몇 의사들이 일본, 미국, 한국등의 의과대학에서는
│ 결코 그런 일이 불가능하다고 말합니다.
│ 그럼, 유박사님이 공부하신 브라질에서는 그 일이 가능했는지요?
┼ ┼
어제는 안식일이라서 인터넷을 열어보지 못해 답변이 늦어져 죄송합니다.
물론 제가 실험을 해본 것은 사실입니다.
아무리 사실이라해도 믿지 못하겠다하면 할 말은 없지요.
그러나 이 과학적 사실은 저 뿐만 아니라 세계적으로 유명한 과학자들에 의하여 이미
밝혀진 것이기 때문에 논문을 하나 올려 드리려 합니다. 영문으로 되어 있는 점 양해해 주시고
필요하신 분들께 알려주시기 바랍니다.
Liver Regeneration
George K. Michalopoulos * and Marie C. DeFrances
Liver regeneration after the loss of hepatic tissue is a fundamental parameter of liver response to injury. Recognized as a phenomenon from mythological times, it is now defined as an orchestrated response induced by specific external stimuli and involving sequential changes in gene expression, growth factor production, and morphologic structure. Many growth factors and cytokines, most notably hepatocyte growth factor, epidermal growth factor, transforming growth factor-, interleukin-6, tumor necrosis factor-, insulin, and norepinephrine, appear to play important roles in this process. This review attempts to integrate the findings of the last three decades and looks toward clues as to the nature of the causes that trigger this fascinating organ and cellular response.
Liver regeneration, having presumably evolved to protect animals in the wild from the catastrophic results of liver loss caused by food toxins, has been an object of curiosity for many years. The ancient Greeks recognized liver regeneration in the myth of Prometheus. Having stolen the secret of fire from the gods of Olympus, Prometheus was condemned to having a portion of his liver eaten daily by an eagle. His liver regenerated overnight, thus providing the eagle with eternal food and Prometheus with eternal torture. In modern times, the best experimental model for the study of liver regeneration is that introduced by Higgins and Anderson (1): a simple operation (partial hepatectomy, PHx) in which two-thirds of the liver of a rat is removed. Specific liver lobes are removed intact, without damage to the lobes left behind. The residual lobes enlarge to make up for the mass of the removed lobes, though the resected lobes never grow back. The whole process lasts 5 to 7 days. Partial hepatectomy is the most often used stimulus to study liver regeneration because, compared with other methods that use hepatic toxins (such as CCl4), it is not associated with tissue injury and inflammation, and the initiation of the regenerative stimulus is precisely defined (removal of liver lobes).
Studies with hepatic resections in larger animals (dogs and primates) and humans have established that the regenerative response is proportional to the amount of liver removed. Even small resections (<10%) are followed by eventual restoration of the liver to full size. When liver from large dogs is transplanted into small dogs, liver size gradually decreases until the size of the organ becomes proportional to the new body size (2). Conversely, in two recent cases of baboon liver transplanted to humans, the transplanted intact liver of the baboon rapidly grew in size (within a week) until it reached the size of human liver (3). These studies demonstrate that liver mass is precisely regulated and that signals from the body can have negative as well as positive effects on liver mass until the correct size is reached
The authors are in the Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Full text를 보시기 원하시면 Science 1997. April 4;276: 60-66쪽을 참고하시면 간의 재생에 대하여
매우 자세하게 게재 되어 있습니다.
간을 부분이식하는 이유도 간이 재생하는 원리 때문입니다.
지금은 간 뿐만 아니라 뇌신경, 심장근육, 신장 등 모든 세포들이 재생한다는 것이 분명히 밝혀져
있습니다. 창조주께서 살아 계시기 때문에 가능한 일입니다.
감사합니다.
================================
┼ ▨ 유박사님, 이 문제 중요합니다!!! - 재림교인(aabb22@chollian.net) ┼
│ 왜 답변이 없으신가요?
│ 유박사님의 "최첨단의학 재생"편에 기록된
│ 대학 4년때의 개 간 절제 수술이 사실인가요?
│ 꼭 답변해 주십시요
│ 지금 몇몇 의사들이 일본, 미국, 한국등의 의과대학에서는
│ 결코 그런 일이 불가능하다고 말합니다.
│ 그럼, 유박사님이 공부하신 브라질에서는 그 일이 가능했는지요?
┼ ┼
